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Latest AOSLO Studies

Kilo-DM Mirror Mount
   Cone Physiology
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Quantitative measures of cone physiology

  • Increasing severity of Diabetic Retinopathy associated with decrease in  cone regularity
  • Diabetic Macular Edema associated with cone mosaic changes, cone reflectance  and decreased regularity of cone spacing

Related work:
Changes in Cone Density, Reflectivity and Regularity  Assessed by AOSLO In Diabetic Retinopathy
J Lammer, A Ahmed, S Prager, M Cheney, SA Burns, PS Silva, LP Aiello, JK Sun, Beetham Eye Institute, Joslin Diabetes Center
Presented at ARVO 2013

Detection of microaneurysms

  • MA wall hyperreflectivity on AOSLO is significantly associated with larger MA size and the presence of retinal inner layer disorganization
  • The presence of a MA lumen clot correlates with larger MA size, but not with neural retinal changes on SD OCT
  • For MA’s located within 500 µm of the foveal center, the presence of wall hyperreflectivity is associated with worse VA, even after adjusting for MA size or inner layer disorganization

Related work:
Structural Characteristics of Microaneurysms on AOSLO and Surrounding Neural Retinal Pathology in Diabetes
JK Sun, PS Silva, SA Burns, LP Aiello,Joslin Diabetes Center, Department of Ophthalmology, Harvard Medical School
Presented at ARVO 2013

Quantitative measures of small-vessel blood flow

  • Retinal vessel blood velocity profile

Related work:
Noninvasive Measurements and Analysis of Blood Velocity Profiles in Human Retinal Vessels
Zhangyi Zhong  et al IOVS, June 2011, Vol. 52, No. 7

Videos © 2012 Beetham Eye Institute, Joslin Diabetes Center. All Rights Reserved. Courtesy JK Sun, MD, MPH

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