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Instrument Functions: Detection of Microaneurysms

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Apaeros gives the ability to detect microaneurysms (MA) which are undetectable by other retinal imaging modalities. The user can examine vascular and neural retinal places in vivo with cell-scale resolution. This may enable researchers to explore how retinal pathology develops, how it affects visual acuity and how it responds to treatment. The following microaneurysm attributes can be measured:

  • Dimension
  • Presence of lumen clot
  • Wall reflectivity
Microaneurysm dimensions Presence of lumen clot all reflectivity
Images © 2012 Beetham Eye Institute, Joslin Diabetes Center.
All rights reserved. Courtesy JK Sun, MD, MPH

Through these capabilities, Apaeros has enabled various investigative studies and publications, specifically:

  • MA wall hyperreflectivity on AOSLO is significantly associated with larger MA size and the presence of retinal inner layer disorganization
  • The presence of a MA lumen clot correlates with larger MA size, but not with neural retinal changes on SD OCT
  • For MA’s located within 500 µm of the foveal center, the presence of wall hyperreflectivity is associated with worse VA, even after adjusting for MA size or inner layer disorganization

More information can be found in the following work:
Structural Characteristics of Microaneurysms on AOSLO and Surrounding Neural Retinal Pathology in Diabetes
JK Sun, PS Silva, SA Burns, LP Aiello,Joslin Diabetes Center, Department of Ophthalmology, Harvard Medical School
Presented at ARVO 2013

List of all related works

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